Abstract
Aims: Rifampicin one of the most commonly used front-line drugs in antituberculosis therapy, has been known to be hepatotoxic. The oxidative stress that is formed in the mitochondria due to rifampicin and isoniazid causes an imbalance in lipid metabolism. This study aims to determine the effect of lowering total cholesterol, triglyceride, and LDL levels and increasing HDL levels of papaya seed ethanol extract in rats induced by rifampin and isoniazid.
 Study design: This study is experimental study.
 Methodology: This study was divided into 9 groups including normal group, negative group 1, 2, 3, positive 1, 2, treatment group I (EECP 100 mg/kgbw), treatment group II (EECP 300 mg/kgbw), and treatment group III (EECP 500 mg/kgbw). Rifampicin (50 mg/kgbw), isoniazid (50 mg/kgbw), and EECP were given 28 days, on day 29 rats were dissected and blood was taken and the total cholesterol, triglyceride, LDL and HDL levels were measured.
 Results: The results showed that the ethanol extract of papaya seeds at a dose of 100 mg / kgbb, 300 mg / kgbb, and 500 mg / kgbw could reduce levels of total cholesterol, triglycerides, LDL and increase HDL levels. The dose of 500 mg / kgbw was not statistically significant (P> 0.05) with the normal group.
 Conclusion: Ethanol extract of Carica papaya has a potential effect of preventing the destruction of lipid metabolism effect by reducing the LDL, Trygliseride, Cholesterol Total, and increasing the level of HDL.
Highlights
Ethanol extract of Carica papaya has a potential effect of preventing the destruction of lipid metabolism effect by reducing the LDL, Trygliseride, Cholesterol Total, and increasing the level of HDL
Tuberculosis (TB) is a chronic infectious disease and is still one of the most serious problems for humans worldwide, which is caused by the bacteria known as Mycobacterium tuberculosis and is characterized by fever and cough [1]
Every year around 850 thousand people with tuberculosis in Indonesia, and 13 people die from tuberculosis every hour [3]
Summary
Tuberculosis (TB) is a chronic infectious disease and is still one of the most serious problems for humans worldwide, which is caused by the bacteria known as Mycobacterium tuberculosis and is characterized by fever and cough [1]. TB disease is a global problem, and still the main infectious disease in Indonesia [2]. With a large population, has a large number of people with tuberculosis, including the top five in the world. In 2016, Indonesia was ranked second in the world with the most TB sufferers [4] (Ministry of Health, 2017). Report to the World Health Organization (WHO) in 2014, the incidence of pulmonary tuberculosis in 2013 was estimated at 450,000 people, 170,000 of whom died [5,6]
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