Abstract
The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.
Highlights
Tujuan penelitian ini adalah untuk membuktikan bahwa pemberian ekstrak daun Jati Belanda (Guazuma ulmifolia Lamk) dapat memperbaiki profil lipid pada darah tikus Wistar jantan dislipidemia
The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p
The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats
Summary
Dipylidiasis Meningkatnya status sosioekonomi dan perubahan gaya hidup termasuk pola makan menyebabkan asupan lemak jenuh meningkat, sedangkan aktivitas fisik makin berkurang (sedentary lifestyle). Konsumsi lemak jenuh tinggi dan kurangnya aktivitas fisik akan menyebabkan penimbunan lemak di jaringan lemak (Haryanto, Pangkahila, Aman, & Siswanto, 2019). Secara umum kondisi ini akan menimbulkan kelainan metabolisme lemak darah yang dikenal sebagai dislipidemia. Dislipidemia dapat bermanifestasi sebagai peningkatan konsentrasi kolesterol total, trigliserida, dan low-density lipoprotein (LDL) serta penurunan high-density lipoprotein (HDL) dalam darah (Widhiantara, Permatasari, Siswanto, & Dewi, 2018). Penanganan yang benar terhadap dislipidemia dapat menurunkan risiko penyakit kardiovaskular pada pasien overweight dan obesitas (Bays et al, 2013). Selain murah dan mudah didapat, memiliki risiko efek samping yang kecil sehingga relatif aman jika dibandingkan dengan obat-obat sintesis (Gravina, Bertolami, & Rodrigues, 2012; Zodda, Giammona, & Schifilliti, 2018). Efek daun Jati Belanda terhadap profil lipid masih harus dibuktikan
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