Abstract
Orthokeratology lenses are commonly used for myopia control, especially in children. Tear lipids and proteins are immediately adsorbed when the lens is put on the cornea, and protein deposition may cause discomfort or infection. Therefore, we established an in vitro protein deposition analysis by mimicking the current cleaning methods for orthokeratology lens wearers for both short-term and long-term period. The results showed that the amounts of tear proteins accumulated daily and achieved a balance after 14 days when the lens was rubbed to clean or not. Protein deposition also affected the optical characteristics of the lens regardless of cleaning methods. Our results provided an in vitro analysis for protein deposition on the lens, and they may provide a potential effective method for developing care solutions or methods that can more effectively remove tear components from orthokeratology lenses.
Highlights
Orthokeratology lenses have been used for affecting vision since 1945, when the corneal contact lens was made with plastic [1]
The current study demonstrated that tear proteins were more adsorbed on the surface of hydrophobic ortho-k lenses in the presence of tear lipids
Both short-term and long-term protein deposition analysis showed that proteins accumulated on the ortho-k lenses, and rubbing could remove significantly more adsorbed proteins than non-rubbing
Summary
Orthokeratology (ortho-k) lenses have been used for affecting vision since 1945, when the corneal contact lens was made with plastic [1]. The safety of wearing ortho-k lenses has been monitored by several long-term clinical follow-ups, and complications still arise, the majority was not immediate adverse events [3]. The possible cause of microbial keratitis might due to lack of eye movements which usually help to disrupt the bacterial glycocalyx, resulting in less spreading of lysozyme over the surface of eye tissue and making eyes being more susceptible to the infection [5]. Tear proteins and lipids are immediately deposited on the surface of the lens when a contact lens is put into the eye. Tear proteins are accumulated on the lens and may cause immune reactions if lenses are not being cleaned completely [8,9]
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