Abstract
The oculomotor vermis (lobulus VI, VII) and its immediate output structure, the caudal part of the fastigial nucleus (fastigial oculomotor region, FOR), participate in the generation of saccades and smooth pursuit eye movements. Lesions to these cerebellar midline structures lead to step-size error dysmetria, with saccades to visual targets being either too large (hypermetric) or too small (hypometric). Smooth pursuit eye movements can have a reduced gain (cogwheel smooth pursuit).An analysis of lesion data in humans and monkeys revealsI. Lesions to the oculomotor vermis have the opposite effect to lesions of the FOR. Whereas a unilateral oculomotor vermis lesion causes hypometric ipsilateral and hypermetric contralateral saccades, FOR lesions lead to hypometric contralateral and hypermetric ipsilateral saccades. Furthermore, bilateral oculomotor vermis lesions lead to hypometric saccades, and bilateral FOR lesions to hypermetric saccades.2. Saccade and smooth pursuit disorders are related. Hypometric sac...
Published Version
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