Effects of ablation of flocculus and paraflocculus of eye movements in primate.

Abstract

ArticlesEffects of ablation of flocculus and paraflocculus of eye movements in primateD. S. Zee, A. Yamazaki, P. H. Butler, and G. GucerD. S. Zee, A. Yamazaki, P. H. Butler, and G. GucerPublished Online:01 Oct 1981https://doi.org/10.1152/jn.1981.46.4.878MoreSectionsPDF (4 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformationCited ByPursuit disorder and saccade dysmetria after caudal fastigial inactivation in the monkeyClara Bourrelly, Julie Quinet, and Laurent Goffart2 October 2018 | Journal of Neurophysiology, Vol. 120, No. 4Dopamine D1 Receptor–Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive BehaviorBiological Psychiatry, Vol. 84, No. 6Microsurgical anatomy and approaches around the lateral recess with special reference to entry into the ponsJournal of Neurosurgery, Vol. 129, No. 3Three concurrently identified types of rebound nystagmus in a case with Arnold-Chiari malformation (Type I)Equilibrium Research, Vol. 77, No. 3Eye Movement Research in the Twenty-First Century—a Window to the Brain, Mind, and More19 December 2017 | The Cerebellum, Vol. 17, No. 3Central Lesions With Selective Semicircular Canal Involvement Mimicking Bilateral Vestibulopathy24 April 2018 | Frontiers in Neurology, Vol. 9The Floccular Syndrome: Dynamic Changes in Eye Movements and Vestibulo-ocular Reflex in Isolated Infarction of the Cerebellar Flocculus26 August 2017 | The Cerebellum, Vol. 17, No. 2Adaptation of the vertical vestibulo-ocular reflex in cats during low-frequency vertical rotationAuris Nasus Larynx, Vol. 45, No. 2The Effect of Visual Contrast on Human Vestibulo-Ocular Reflex Adaptation6 November 2017 | Journal of the Association for Research in Otolaryngology, Vol. 19, No. 1Neuro-ophthalmologic assessment and investigations in children and adults with cerebellar diseasesVisual and ocular motor function in the atypical form of neurodegeneration with brain iron accumulation type I9 May 2017 | British Journal of Ophthalmology, Vol. 102, No. 1Responses of Purkinje cells in the oculomotor vermis of monkeys during smooth pursuit eye movements and saccades: comparison with floccular complexRamanujan T. 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Miles1 October 1998 | Journal of Neurophysiology, Vol. 80, No. 4Recording Eye Movements in Mice: A New Approach to Investigate the Molecular Basis of Cerebellar Control of Motor Learning and Motor Timing17 May 2016 | Otolaryngology-Head and Neck Surgery, Vol. 119, No. 3Short-term vestibulo-ocular adaptation: Influence of context17 May 2016 | Otolaryngology-Head and Neck Surgery, Vol. 119, No. 1Noradrenergic influences on the cerebellar cortex: Effects on vestibular reflexes under basic and adaptive conditions17 May 2016 | Otolaryngology-Head and Neck Surgery, Vol. 119, No. 1Effect of Cerebellar Inactivation by Lidocaine Microdialysis on the Vestibuloocular Reflex in GoldfishJames G. McElligott, Phyllis Beeton, and Jeffrey Polk1 March 1998 | Journal of Neurophysiology, Vol. 79, No. 3Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular ReflexNeuron, Vol. 20, No. 3Comparison of Two Methods of Producing Adaptation of Saccade Size and Implications for the Site of PlasticityCharles A. Scudder, Ekatherina Y. Batourina, and George S. Tunder1 February 1998 | Journal of Neurophysiology, Vol. 79, No. 2Participation of Caudal Fastigial Nucleus in Smooth Pursuit Eye Movements. II. Effects of Muscimol InactivationFarrel R. Robinson, Andreas Straube, and Albert F. Fuchs1 August 1997 | Journal of Neurophysiology, Vol. 78, No. 2Prediction of Complex Two-Dimensional Trajectories by a Cerebellar Model of Smooth Pursuit Eye MovementR. E. Kettner, S. Mahamud, H.-C. Leung, N. Sitkoff, J. C. Houk, B. W. Peterson, and A. G. Barto1 April 1997 | Journal of Neurophysiology, Vol. 77, No. 4Testable predictions from recurrent backpropagation models of the vestibulo-ocular reflexNeurocomputing, Vol. 6, No. 2Noradrenergic agents in the cerebellar vermis affect adaptation of the vestibulospinal reflex gainBrain Research Bulletin, Vol. 35, No. 5-6Visual-vestibular interaction in the control of head and eye movement: The role of visual feedback and predictive mechanismsProgress in Neurobiology, Vol. 41, No. 4The cerebellum as a predictor of neural messages—I. The stable estimator hypothesisNeuroscience, Vol. 56, No. 3The cerebellum as a predictor of neural messages—II. Role in motor control and motion sicknessNeuroscience, Vol. 56, No. 3Responses of floccular Purkinje cells to sinusoidal vertical rotation and effects of muscimol infusion into the flocculus in alert catsNeuroscience Research, Vol. 17, No. 4Central neuroanatomical organisation of the rat visuomotor systemProgress in Neurobiology, Vol. 41, No. 2Up–down Asymmetry in Vertical Induced Motion25 June 2016 | Perception, Vol. 22, No. 5The neuronal substrate of integration in the oculomotor systemProgress in Neurobiology, Vol. 39, No. 6Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulationNeuroscience Research, Vol. 12, No. 5Contribution of eye muscle proprioception to velocity-response characteristics of eye movements: involvement of the cerebellar flocculusNeuroscience Research, Vol. 12, No. 1Generation of smooth-pursuit eye movements: neuronal mechanisms and pathwaysNeuroscience Research, Vol. 11, No. 2Induced Motion: Isolation and Dissociation of Egocentric and Vection-Entrained Components25 June 2016 | Perception, Vol. 20, No. 3Identification of the Purkinje cell/climbing fiber zone and its target neurons responsible for eye-movement control by the cerebellar flocculusBrain Research Reviews, Vol. 16, No. 1Selective nonconjugate binocular adaptation of vertical saccades and pursuitsVision Research, Vol. 30, No. 11Vestibular and visual signals in the ventral paraflocculus of the cerebellum in rabbitsNeuroscience Letters, Vol. 108, No. 1-2Role of the nucleus of the optic tract of monkeys in optokinetic nystagmus and optokinetic after-nystagmusBrain Research, Vol. 474, No. 1ENG-MRI Correlates in Cerebellar Oculomotor Dysfunction1 September 1988 | Otolaryngology-Head and Neck Surgery, Vol. 99, No. 3Cerebellar involvement in the coordination control of the oculo-manual tracking system: effects of cerebellar dentate nucleus lesionExperimental Brain Research, Vol. 73, No. 1Induced motion and optokinetic afternystagmus: Parallel response dynamics with prolonged stimulationVision Research, Vol. 28, No. 6Down beating nystagmus: Magnetic resonance imaging and neuro-otological findingsJournal of the Neurological Sciences, Vol. 81, No. 2-3Response properties and visual receptive fields of climbing and mossy fibers terminating in the flocculus of the monkeyExperimental Neurology, Vol. 95, No. 2Detection of tracking errors by visual climbing fiber inputs to monkey cerebellar flocculus during pursuit eye movementsNeuroscience Letters, Vol. 72, No. 2Clinico-topographic correlation of small vertebrobasilar infarct using magnetic resonance imaging.Stroke, Vol. 17, No. 5Role of the nucleus of the optic tract in monkeys in relation to optokinetic nystagmusBrain Research, Vol. 364, No. 1Horizontal optokinetic ocular nystagmus in the pigmented ratNeuroscience, Vol. 15, No. 1Cerebellar vermis involvement in monkey saccadic eye movements: MicrostimulationExperimental Neurology, Vol. 86, No. 3Development of vertical vestibulo-ocular reflex characteristics in intact and flocculectomized rabbits visually deprived from birthBehavioural Brain Research, Vol. 13, No. 3Vestibular Neurophysiology11 December 2016 | Otolaryngology-Head and Neck Surgery, Vol. 92, No. 1New Concepts of Cerebellar Control of Eye Movements11 December 2016 | Otolaryngology-Head and Neck Surgery, Vol. 92, No. 1Disorders of Eye MovementsNeurologic Clinics, Vol. 1, No. 4Role of the cerebellum during motor learning in the vestibulo-ocular reflexTrends in Neurosciences, Vol. 5Kinematic model relating complex 2D smooth pursuit eye movements and Purkinje cell firing rate in cerebellar flocculus and paraflocculus of the rhesus monkeyAnalysis of cerebellar flocculus Purkinje cell firing patterns during visual vestibular interactions before and in the process of VOR motor learning More from this issue > Volume 46Issue 4October 1981Pages 878-899 Copyright & PermissionsCopyright © 1981 the American Physiological Societyhttps://doi.org/10.1152/jn.1981.46.4.878PubMed7288469History Published online 1 October 1981 Published in print 1 October 1981 Metrics