The Effect of Bacterial Infection with Helicobacter pylori on Thyroid Hormones

Abstract

Objective: Our current research aimed to see if there was a link between Helicobacter pylori infection and thyroid hormone levels. Methods: In Karbala, Iraq, samples were obtained from 84 individuals with H. pylori (42 patients tested positive for H. pylori antigen test and 42 patients tested negative) between December 2021 and January 2022. All subjects had five milliliters of whole blood drawn into clot tubes and centrifuged for 30 minutes to obtain serum. Enzyme-linked immunosorbent assay (ELISA) kits were used to measure the amounts of free T4 and TSH in the blood. Results: Females are more susceptible to H. pylori infection than males (p = 0.00001), according to the findings. Furthermore, the mean age of positive test patients is 49.66 years, which is considerably (p = 0.0177) higher than the mean age of negative test patients (43.38 years), and the oldest men are more infected with H. pylori than young men. The results show no significant variations in free T4 concentrations between males and females for both positive and negative tests (p > 0.05). This implies that while infected with H. pylori, the concentration of free T4 was unaffected. Finally, H. pylori infection causes a considerable increase in stomach acid, according to the research. (p = 0.0037) in FSH levels in both sexes. Conclusions: We can determine that females are more likely than males to be infected with H. pylori. And that most patients are aged, particularly men. Furthermore, there is no partnership between H. pylori infection and free F4 hormone levels, and patients with H. pylori have a higher FSH hormone concentration than those with a negative H. pylori antigen test.