Abstract

a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.

Highlights

  • The hippocampus is an important part of the brain

  • Plate 2 showed reactive astrocytes with prominent cell processes wrapped around injured neurons

  • A high level of Glial fibrillary acidic protein (GFAP)-reactive astrocyte expression was observed in plate 2 which were treated with Diazepam alone

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Summary

Introduction

The hippocampus is an important part of the brain. It is small in structure and it plays a critical role in the formation, organization and storage of new memories, as well as the connection of certain sensations and emotions to these memories.[1]. The fruit is green when small but turns yellow or orange when ripe and is known to possess health promoting compounds, including flavonoids, alkaloids, tanins and saponins.[10] The entire fruit is edible, and of high nutritive value. It is known for its medicinal uses traditionally, especially in the treatment of digestive tract disorders, diabetes mellitus, lowering of blood pressure, as well as anti-cancer, anti-dotal and anti-microbial effects. In view of these facts, the study investigated the effects of aqueous Averrhoa carambola fruit extract on the hippocampus of Diazepam-induced neurotoxicity in female Wistar rats

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