Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
C. paradisi, popularly known as grapefruit, is widely grown in most nations and its height is about 3-5 metres with bright yellow colorations[1]
Numerous researches have insinuated that carbon tetrachloride is the most formidable needed during the activation reactive oxygen species (ROS) in different tissues.[11]
The present study is aimed at evaluating the nephrotoxic property of aqueous seed extract of C. paradisi by investigating its effects on serum electrolytes at the oral dose of 125-500 mg/kg/day of the extract on the nephrotoxic features in Wistar rats
Summary
C. paradisi, popularly known as grapefruit, is widely grown in most nations and its height is about 3-5 metres with bright yellow colorations[1]. The major bioflavonoid in grapefruit is naringen that gives grapefruit juice a bitter taste.[6,7] Naringen possesses anti-carcinogenic activity[6] and blockage of precise cytochrome P450 enzymes such as CYPIA2.8 Carbon tetrachloride (CCl4) is commonly known as tetrachloromethane, Halon-104, and Refrigerant-10.9 Carbon tetrachloride is potent used in the generation of experimental models in oxidative stress in many pathophysiological occurrences.[9,10] Numerous researches have insinuated that carbon tetrachloride is the most formidable needed during the activation reactive oxygen species (ROS) in different tissues.[11] Due to the administration of carbon tetrachloride, superoxide anion, hydrogen peroxide and superoxide anion are produced because of oxidative stress leading to the generation of ROS.[12] It is disclosed that carbon tetra chloride-induced oxidative stress steers nephrotoxicity leading to several uncontrolled disorders causing general kidney failure.[13,14] This situation that can enhance mortality and morbidity arising from disease conditions traceable to cellular oxidative stress calls for the search for a solution in substances that could attenuate oxidative stress. The present study is aimed at evaluating the nephrotoxic property of aqueous seed extract of C. paradisi by investigating its effects on serum electrolytes at the oral dose of 125-500 mg/kg/day of the extract on the nephrotoxic features in Wistar rats
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