Abstract
The success of encapsulation to protect iron from inhibitor degradation or oxidation depends on many factors including the excipient characteritics. Glucomannan, a neutral heterosaccharide, has a potential for the excipient. To improve the excipient performances, glucomannan is deacetylated to remove the acetyl groups by reacted with Na2CO3. This deacylated glucomannan is subject to bead formation after iron loading. The alcohol solution is commonly used in bead forming as dehydration medium during the encapsulation process. The objective of this work was to study the effect of alcohol on the bead performance of encapsulated iron using deacetylated glucomannan. The bead forming was conducted by dropping the excipient into ethanol and isopropyl alcohol (IPA) solution at various concentrations (50, 60, 70, 80 and 90%) and two condition temperatures (27-30° and 7-10°C). The encapsulation samples were subject to yield (YE) and efficiency of encapsulation (EE). The concentration of alcohol showed a positive impact on the yield and efficiency of encapsulation. Ethanol has a better performance compared with that of IPA regarding yield and efficiency of encapsulation. The optimum of yield bead formation (69.67%) and highest EE (66.80%) were obtained at 90% ethanol. Temperature of dehydration did not affect the YE and EE significantly.
Highlights
Encapsulation techniques have been developed broadly to accommodate various purposes
The succeed of encapsulation in protecting the iron from inhibitor degradation or oxidation depends on many factors e.g. the excipient properties and preparation condition [1],[6]
Since iron was sensitive to be oxidized, solvent evaporation was selected as a method to form beads during iron encapsulation using deacetylated glucomannan
Summary
Encapsulation techniques have been developed broadly to accommodate various purposes. Among of the purposes of encapsulation are to protect the sensitive substances from the external environment, to mask the organoleptic properties like color, taste, odor of the substance, to obtain controlled release of the drug substance, for safe handling of the toxic materials, and to get targeted release of the drug [1]. Iron is one of the essential micronutrients that urgently develop into encapsulated form since it is oxidized when exposed to air. The succeed of encapsulation in protecting the iron from inhibitor degradation or oxidation depends on many factors e.g. the excipient properties and preparation condition [1],[6]
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