Abstract
SUMMARY 1. Experiments were performed in animals to determine the effect of acutely induced respiratory and metabolic alkalosis on cardiac output, and peripheral resistance. 2. Acute respiratory alkalosis produced no change in cardiac output, peripheral resistance, or arterial blood pressure. 3. Acute metabolic alkalosis induced by injection of either hypertonic or isotonic sodium bicarbonate produced a marked increase in cardiac output with an accompanying fall in peripheral resistance but no change in arterial pressure or pulse rate. 4. Control experiments with injection of similar amounts of hypertonic or isotonic sodium chloride solution produced increases in cardiac output similar to those induced by sodium bicarbonate. 5. The elevation in cardiac output induced by intravenous administration of sodium bicarbonate solution appears to be largely explainable on the basis of increased blood volume and no specific effect of acute metabolic alkalosis on cardiac output was demonstrated.
Published Version
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