Abstract
The air flow dynamics of the maximal voluntary cough were studied in 25 patients with bronchial asthma and pulmonary emphysema, and 18 healthy subjects before and after the inhalation of a new bronchodilator aerosol consisting of 0.4 per cent isoproterenol and 2.0 per cent phenylephrine in 10 per cent propylene glycol.Marked resistance in the expiratory air flow of the patient group was reflected in the pneumotachographic tracings of the peak and mean air flow rate, and volume of air expelled with cough. Significant improvement occurred after the inhalation of the bronchodilator aerosol, as contrasted with the lack of change in the healthy subjects.The alterations in the mechanics of cough occurring in obstructive dyspnea and their effect on bronchial drainage are discussed. Relief of bronchospasm by means of a new bronchodilator combination resulted in a more effective cough with no adverse side effects in the 43 subjects studied.
Published Version
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