Abstract
Elevated Advanced Glycation End product (AGE) levels are associated with certain impaired health states. As these are disruptive to the function of healthy tissues, due to their protein cross-linking ability, AGEs are significant contributors to the aging process. In fact, population studies have revealed that AGE levels tend to increase as we get older. Certain lifestyle and dietary factors may accelerate AGE accumulation. Therefore, strategies intended to modify these factors, or mitigate their effects, may be useful in controlling the aging process. In an 11 week open-label clinical trial, 30 adult volunteers consumed daily a commercially available combination of white kidney bean extract, dietary fibers, &beta-carotene and noni ( Morinda citrifolia ) fruit pulp, in combination with calorie restriction and exercise. During the course of the trial, participants experienced significant weekly declines in average body weight and fat mass. The average AGE score, as measured by skin auto-fluorescence, had also decreased significantly. In terms of AGE associated years, the change in AGE scores corresponded to an average decrease of 8.83 years. The results indicate that the intervention contributed to improved health and exhibited anti-aging properties.
Highlights
Advanced Glycation End Products (AGEs) are produced in the body via several mechanisms, including non-enzymatic glycation of proteins, or Maillard reactions (Singh et al, 2001)
AGEs are disruptive to the normal function of healthy tissues due to their protein cross-linking ability
The binding of AGEs to their specific cellular receptors (RAGE) initiates transcription of Nuclear Factor kappa beta (NF-kβ). This results in increased expression of pro-oxidant and pro-inflammatory genes, as well as the production of additional RAGE, all of which promote accelerated AGE formation (Brownlee, 2001; Ramsey et al, 2012)
Summary
Advanced Glycation End Products (AGEs) are produced in the body via several mechanisms, including non-enzymatic glycation of proteins, or Maillard reactions (Singh et al, 2001). The binding of AGEs to their specific cellular receptors (RAGE) initiates transcription of Nuclear Factor kappa beta (NF-kβ) This results in increased expression of pro-oxidant and pro-inflammatory genes, as well as the production of additional RAGE, all of which promote accelerated AGE formation (Brownlee, 2001; Ramsey et al, 2012). Dietary scanner uses the principle of skin auto-fluorescence to fiber intake is reported to have positive effects on measure AGE levels and is based on clinically validated body weight, metabolic syndrome and blood glucose methods (Meerwaldt et al, 2004). The TruAge scanner provides an current study was designed and conducted to investigate the efficacy of daily ingestion of a combination of white kidney bean extract, dietary fiber, β-carotene and noni fruit pulp in reducing AGE levels and body mass. Skin auto-fluorescence has been correlated with chronological age in multiple population studies
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