The Dosage of the Avocado Leaf Extract (Persea americana Mill.) on Regeneration of Diabetic White Rats (Rattus norvegicus) Renal Cell

Abstract

Context: Antioxidant activity in avocado leaves plays a role in improving insulin work in controlling blood glucose levels. Aim: To analyse the effect of doses of avocado leaf extract on the regeneration of diabetic rat renal cells. Methods: Experimental method was used with 18 male white rats as subjects. White rats were divided into six groups: Treatment G1: Feed + STZ (Streptozotocin) + Sucrose 10% + Avocado leaf extract dose of 100 mg/kg body weight + NaCMC 0.5%, G2: Feed + STZ + Sucrose 10% + Avocado leaf extract 150 mg/kg body weight + NaCMC 0.5%, G3: Feed + STZ + Sucrose 10% + Avocado leaf extract dose 200 mg/kg body weight + Na-CMC 0.5%, G4: Feed + STZ + 10% sucrose + Na-CMC 0.5%, G5: Feed + STZ + 10% sucrose + Glibenclamid + Na-CMC 0.5%, and P6: Feed. Results: The average renal damage of rats in the rat group was G1 = 1.66; G2 = 1.33; G3 = 0; G4 = 3; P5 = 0; P6 = 0. Score 0 = no damage. Score 1 = mild renal cell damage (1/3 cell part); score 2 = moderate renal cell damage (2/3 cell parts); score 3 = severe renal cell damage (>2/3 cell parts). Conclusion: The treatment of G3 with a dose of 200 mg/kg body weight avocado leaf extract gives a relatively effective influence on regenerating STZ induced renal cell rats, compared to other doses.