Abstract
Objective To investigate the genetic predisposing factor of chronic obstructive pulmonary disease (COPD) by studying the distribution of vitamin D receptor (VDR) gene polymorphisms in patients with COPD in Changsha. Methods Totally 120 COPD patients and 120 volunteers were enrolled in the study. Polymorphisms of VDR genes including Apa I and Bsm I were detected with polymerase chain reaction-restriction fragments length polymorphism (RFLP). Results There existed statistical difference in polymorphism of Apa I gene and frequency of distribution on its allele between two groups (P 0.05). Conclusions COPD is associated with the polymorphism of VDR-Apa I. There may be no relationship on VDR-Bsm I between two groups. Key words: Pulmonary disease, chronic obstructive/GE; Receptors, calcitriol/GE; Polymorphism, single nucleotide
Published Version
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