The diagnostic value of serum human neutrophilic apolipoprotein in infectious diseases of orthopedics

Abstract

Objective To study the serum human neutrophilic apolipoprotein (HNL), white blood cell (WBC) and neutrophil counts, procalcitonin (PCT), ESR and C-reactive protein (CRP) levels in orthopaedic diseases, and to explore the significance of HNL levels in the identification of infectious diseases in orthopaedic diseases. Methods Orthopaedic diseases were selected from Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, including 185 non-infectious cases (spinal and joint degenerative disease, closed fractures, bone and soft tissue tumor), and 60 infectious cases (osteomyelitis, various postoperative infection and chronic ulcer). Serum HNL level, WBC and neutrophil counts, PCT, ESR and CRP levels were determined, and statistically analyzed. The diagnostic efficacy of HNL, WBC and neutrophil counts, PCT, ESR and CRP levels in orthopedic infectious diseases was evaluated by ROC curves. Results Levels of HNL: non-infected group 141.28±63.11 and the infected group 229.96±107.62, the difference was statistically significant (t=-7.819, P AUCESR (0.752) >AUCCRP (0.676) >AUCPCT (0.534) >AUCNBC (0.528) >AUCWBC (0.481). The HNL cut-off value for the diagnosis of bone infectious diseases was 120.1 μg/L. Conclusion HNL can be used as a reference index to distinguish infection from non-infection in orthopaedic diseases, and its efficacy is better than the traditional white blood cell and neutrophil count, ESR, CRP and PCT. Key words: Orthopaedic; Infection disease; Human neutrophil apolipoprotein