Analysis on the value of PCT, CRP, WBC count and Nst detection in the diagnosis of early neonatal infection

Abstract

Objective To analyze the value of procalcitonin (PCT) and C-reactive protein (CRP), white blood cell (WBC) count and neutrophilic stab granulocyte (Nst) detection in the diagnosis of early neonatal infection. Methods Fifty newborns infected in early stage were selected as experimental group and another 50 uninfected newborns at the same period were selected as control group according to the randomized, double blind and control principle. Electrochemiluminescence, immunonephelometry and electrical impedance methods were conducted to detect the levels of PCT, CRP and count WBC in whole blood, while flow cytometry was used for differential counting of WBC to investigate the value of PCT, CRP, WBC count and Nst detection in the diagnosis of neonatal infection. Results The detection result and positive rate of Nst in experimental group were (12.3±10.5)×109/L, 48.00%, respectively, and those were (5.0±4.4)×109/L, 20.00% in control group, the difference was significant (P 0.05). In experimental group, the levels of CRP, PCT and WBC count before treatment in the patients with severe infection were higher than that in patients with mild infection; after treatment, there was no significance in the levels of CRP, PCT and WBC between patients with severe infection and patients with mild infection (P>0.05). Conclusions PCT, CRP, WBC count and Nst detection conduces to improve the accuracy and sensitivity of diagnosis for early-onset neonatal infection and provide reference for clinical treatment, which is worthy of promotion. Key words: Procalcitonin; C-reactive protein; White blood cell count; Neutrophilic stab granulocyte; Neonatal infection