Abstract
SOON after Zondek and Aschheim made their brilliant discovery of the mouse test for pregnancy (1), Shapiro and Zwarenstein (5), Hogben (3), and Bellerby (2) showed the clinical application of the South African Frog (Xenopus laevis) to the finding of gonadotropic hormones in the urdne of pregnancy. In its natural habitat, the female of this unique species of amphibia never lays eggs unless stimulated by the male. Shapiro and Zwarenstein (6) segregated the females from the males and found that ovulation and external egg deposition could be induced entirely at will by simply injecting concentrates of pregnancy urine into these ever-ready and ever-willing female Xenopus. And thus, the early foundation for the frog test for pregnancy was laid. Since 1939, we in America have studied Xenopus laevis in detail and have performed thousands of pregnancy tests with the animal (7, 8, 9, 10, 11).1 In our earlier papers we have reported our excellent results, and have registered our keen delight with Xenopus as a test a...
Published Version
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