Abstract
A nonelectroactive anticancer drug 6‐thioguanine was determined by differential pulse stripping voltammetry on the DNA‐modified gold electrode. The electrode was prepared by the dry adsorptive method, which is simple and direct. Potassium ferricyanate [K3Fe(CN)6] was chosen as an appropriate electroactive indicator to probe and characterize the interaction since the 6‐thioguanine and DNA both are nonelectroactive over the potential range studied. The reductive peak current of K3Fe(CN)6 is linear with the concentration of 6‐thioguanine in the range of 2.0×10−8∼8.0×10−7 mol L−1. The detection limit is 6.0×10−9 mol L−1. The established method was successfully applied to determining trace 6‐thioguanine with the recoveries between 95.7% and 105.6%.
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