The detection value of (1, 3)-β-D-glucan in clinical deep fungal infection

Abstract

Objective To discuss the detection value of(1, 3)-β-D-glucan in the early diagnosis of fungal infection in clinic. Methods 86 patients with deep fungal infection were selected as the study group, and 24 cases of healthy volunteers were selected as the control group, all groups took plasma G test, while cultivating specimens suspected infection and deep fungal infections in patients were divided according to culture-negative group and positive group, plasma G test results were compared. Results In the control group, G test was (6.12±2.87)×10-3ng/mL in plasma, deep fungal infection negative, positive test results were (32.58±24.12)×10-3ng/mL and (101.28±36.04)×10-3ng/ mL in plasma G respectively, positive group G results in plasma were significantly increased, the differences were statistically significant(t=18.28, 7.92, P=0.036, 0.042); both positive plasma G test results were significantly higher than that of the negative group, the difference was statistically significant(t=12.16, P=0.038). Plasma G test positive diagnosis of deep fungal infection was 79.1%, significantly better than the fungal culture 50.0%, the difference was statistically significant(χ2=31.26, P=0.002). Conclusion In early clinical diagnosis of deep true infection, plasma G test positive rate is higher than fungal culture, and is worthy of wider application. Key words: Dextran; Fungal infections; Laboratory diagnosis