Abstract
Summary Among our female breeder rats, there is a high incidence of post-reproduction arteriopathy due to forced weaning of their offspring. In the chronic stage, these vascular lesions are very similar to the so-called spontaneous arteriosclerosis of breeder rats which has been described previously by other authors. The present report deals with the influence of 3 different standardized diets on the development of this arteriopathy in rats. The vascular lesions were found to occur after only 1 of these 3 diets. On the other hand, biochemical changes in the blood calcium and/or phosphorus levels were observed (after forced weaning) with all the diets investigated. These results do not support our previous hypothesis concerning the basic importance of changes in the level of blood phosphorus in the pathogenesis of post-reproduction arteriopathy (beginning as pure mediocalcinosis), even though fluctuations in the blood calcium and phosphorus levels after forced weaning should be studied further in this context.
Published Version
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