Effect of clofibrate and high fat diets on adrenaline-induced lipolysis in isolated rat adipose tissue

Abstract

Adipose tissue from rats fed high fat diets were found to exhibit significantly less adrenaline-induced FFA release than those from rats maintained on low fat commercial diet. Addition of CPIB to the high fat diet reversed this suppression of adrenaline-induced FFA release by isolated adipose tissue. Supplementation of the diet with cholesterol-cholate also reversed the suppressive effect of high dietary fat on adrenaline-induced lipolysis in vitro . Adrenaline-induced FFA release in adipose tissue seems to depend upon the metabolic status of the tissue as determined by previous nutrition of the animal.