Abstract
Objective To investigate the therapeutic effect of topical corticosteroids injection and systemic application in the treatment of sudden hearing loss. Methods Total of 58 patients with sudden hearing loss were randomly divided into two groups.The systemic application group:dexamethasone(DEX) was applied by intravenous injection in dose of 10mg×3d,followed by 5mg×4d.And the postauricular injection group: methylprednisolone sodium succinate of 40mg was injected into cortical bone of mastoid region every three days, until hearing back to normal,or 15 days.SPSS 13.0 software was used to analyze the data. Results The total effective rate of systemic application group was 67.7%,the total effective rate of postauricular injection group was 64.7%.There was no statistical difference between the two groups(χ2= 2.58,P= 0.316).The recovery rate in cases with postauricular injection group was significantly increased in comparison with the systemic application group,but no statistical difference between the two groups(t= 2.71,P= 0.062).Patients with hearing loss in low frequencies(250Hz,500 Hz),the recovery rate in cases with postauricular injection group was significantly increased in comparison with the systemic application group(t= 3.82,P= 0.031;t= 3.26,P= 0.042). Conclusion Postauricular topical injection and systemic application of glucocorticoids in the treatment of sudden hearing loss are all have good curative effect.Systemic application is selected by conventional treatment,and topical injection has a better effect in the hearing loss of low-middle frequencies. Key words: Hearing loss; Sudden; Glucocorticoids; Drug administration routes
Published Version
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