The correlation between thyroid nodular and thyroid calcification

Abstract

Objective To explore the relation between thyroid nodular and thyroid calcification .Methods The clinical data of 430 cases with nodular goiter admitted from January 2011 to December 2013 were reviewed.All cases were performed ultrasonography and pathologic examination .Results Of 430 cases,there was thyroid carcinoma in 49 cases（11.4%）,including microcalcification in 30 cases（61.2%） and macrocalcification in 3 cases（6.1%）;benign lesion in 381 cases（88.6%）,including microcalcification in 24 cases（6.3%） and macrocalcification in 39 cases（10.2%）.The difference was remarkable （P=0.000）.There was remarkable difference in malignant calci-fied nodules ratio between the patients with microcalcification and macrocalcification （55.6%vs 7.1%,P=0.000）, between the patients aged 45 years below and above（48.8%vs 22.6%,P=0.007）,between the patients with solita-ry and multiple nodules（45.0%vs 16.7%,P=0.005）.But there was no statistic difference in malignant calcified nodules ratio between the male and female groups （24.2% vs.39.7%,P=0.130）.Conclusion Microcalcification is a highly specific sign to predict thyroid carcinoma in ultrasonography exam .Positive intervention will be performed immediately when calcification appears in thyroid nodules . Key words: Thyroid neoplasms; Goiter; Calcifying nanoparticles; Ultrasonography,doppler,color