The comparison of the effect of rosuvastatin and simvastatin on myocardial infarction in patients with C reactive protein and matrix metalloproteinase-9

Abstract

Objective To the difference between the effects which rosuvastatin and simvastatin make in patients of myocardial infarction serum c-reactive protein and matrix metalloproteinases-9 levels of influence.Methods Select from September 2010 to January 2012 were of our 82 patients with myocardial infarction,diagnosis which conform to the 2007 version of acute myocardial infarction in the diagnosis and treatment of guide standard,come on time in 24 h are within,choose the 82 cases of myocardial infarction patients for the test group in that same period,select 82 cases for health in the control group.82 cases of myocardial infarction patients were randomly divided into 2 groups:respectively:①simvastatin group (simvastatin + conventional medicine ); ②rosuvastatin group (rosuvastatin + conventional medicine ).Were measured before and after treatment of plasma high-sensitivity C reactive protein, matrix metalloproteinases-9 concentration.Methods 60 cases of healthy people in the control period.Results In patients with acute myocardial infarction plasma high-sensitivity C reactive protein, matrix metalloproteinases-9 determination value are higher than that of control group ( P ＜0.01 ) ; the rosuvastatin group and simvastatin group after the treatment of plasma high-sensitivity C reactive protein and matrix metalloproteinases-9 determination value were obviously lower than those before therapy level ( P ＜ 0.01 ),And rusuvastatin compared with simvastatin can reduce the patients with C reactive protein and matrix metalloproteinases-9 level,two has statistics difference ( P ＜ 0.01 ). Conclusions Rosuvastatin can reduce the myocardial infarction patient blood serum C response protein and matrix metalloproteinases-9levels better than that of simvastatin. Key words: Rosuvastatin ; Simvastatin ; C reactive protein; Matrix metalloproteinases-9