Abstract
The purpose of this study was to evaluate the co-prescription efficacy of esomeprazole and flupenthixol/melitracen relative to that of solitary esomeprazole on erosive gastritis complicated with negative feelings. 140 erosive gastritis patients complicated with negative feelings enrolled in the present study. Seventy cases in the control group took esomeprazole, and 70 cases in the observation group received esomeprazole plus flupenthixol/Melitracen, both for 4 weeks. We gastroscopically checked the clinical symptoms, mucosal erosion, PGE2 and MDA levels in gastric mucosa, anxiety, depression, and recurrence before and after treatment in the groups. After treatment, the observation group had lower scores of clinical symptoms, mucosal erosions, Hamilton Depression Rating Scale (HAMD), and Hamilton Depression Rating Scale (HAMA) than the control group (p<0.05); as well, the observation group showed higher PGE2 and lower MDA levels than the control group (p<0.05); during six months of follow-up (100% follow-up rate), 16 and 34 recurrent cases occurred, respectively, in the observation and control groups (p<0.05). Co-prescription of esomeprazole and flupenthixol/melitracen improved the clinical symptoms and mucosal erosions, relieved negative feelings and reduced the recurrence rate. The efficacy of the co-prescription is higher than that of the solitary prescription.
Highlights
As a common gastrointestinal disease, chronic erosive gastritis is indicated by a variety of signs extending from nausea and obscure gastric inconvenience to anorexia, vomiting, and weight loss [1, 2]
General materials A total of 140 erosive gastritis patients with negative feelings referred to Chongqing hospital since January 2015 to December 2016 were enrolled in this study in accordance with the following inclusions: a) patients who have abdominal pain or distension, sour regurgitation, or belching; b) patients who have gastroscopically erosive alterations in the gastric mucosa; c) patients who have chronic negative feelings (HAMA score > 18 points; Hamilton Depression Rating Scale (HAMD) score > 18 points); d) voluntary patients
PGE2 and MDA analysis results In the pretreatment condition, no significant difference existed between the groups regarding comparing PGE2 and MDA levels in the gastric mucosa (p>0.05)
Summary
As a common gastrointestinal disease, chronic erosive gastritis is indicated by a variety of signs extending from nausea and obscure gastric inconvenience to anorexia, vomiting, and weight loss [1, 2]. Helicobacter pylori-induced atrophic gastritis is epidemiologically related to gastric carcinoma [3, 4]. Under the effect of inflammatory factors, the gastric mucosal tissues might lead to atrophic gastritis. The decrease in blood supply, as well as damage and stimulation caused by various inflammatory factors, alterations, and atypical hyperplasia, might lead to gastric carcinoma a silent killer with the hidden onset and slow progression but tremendous damages [6]. In the present paper we compared the coprescription efficacy of esomeprazole and flupenthixol/ melitracen (as an antipsychotic/anxiolytic) with the prescription of solitary esomeprazole on erosive gastritis with negative feelings
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