Clinical study of the high frequency transcranial magnetic stimulation in the treatment of non motor symptoms of Parkinson's disease

Abstract

Objective To explore the clinical effect of the high frequency transcranial magnetic stimulation in the treatment of Parkinson's non motor symptoms. Methods 80 patients with Parkinson's disease were randomly divided into observation group and control group by using random number table, 40 cases in each group.The patients in the observation group received high-frequency repetitive transcranial magnetic stimulation treatment based on the conventional anti-Parkinson's disease drugs.The patients of the control group were treated with conventional anti-Parkinson's disease drugs.The therapeutic effect of the two groups was compared, The test results of the unified Parkinson's disease, Hamilton depression scale, scores of Pittsburgh sleep quality index before and after treatment were analyzed in the two groups. Results After treatment for 7 days and 1 month, the unified Parkinson's disease rating scale test results of the observation group were (29.1±7.3)points, (29.5±6.9)points, respectively, which were significantly lower than (38.6±9.8)points before treatment, the difference was statistically significant(F=4.881, P<0.05). After treatment for 7 days, the Hamilton depression scale score of the observation group was (8.33±4.01)points, which was significantly lower than (13.55±8.27)points of the control group (t=2.356, P<0.05). After treatment for 1 month, the Hamilton depression scale score of the observation group was (8.01±3.87)points, which was significantly lower than (12.98±8.34)points of the control group , the difference was statistically significant(t=3.018, P<0.05). After treatment for 7 days, the Pittsburgh sleep quality index between the two groups had statistically significant difference [(19.7±2.2)points in the observation group, (16.1±1.1)points in the control group, t=2.371, P<0.05]. After treatment for 1 month, the Pittsburgh sleep quality index of the observation group was (26.5±1.3)points, which was significantly higher than (17.2±1.2)points of the control group , the difference was statistically significant(t=3.004, P<0.05). Conclusion The high frequency transcranial magnetic stimulation in the treatment of non motor symptoms of Parkinson's disease can significantly improve the patients' movement, speech, consciousness, emotion, sleep quality, and the effect is good. Key words: Parkinson disease; Transcranial magnetic stimulation; Comparative effectiveness research