The clinical value of combined detection of plasma Lp-PLA2 and D-dimer in patients with hypertension complicated with stroke

Abstract

Objective To investigate the predictive value of plasma lipoprotein phospholipase A2(Lp-PLA2) and D-dimer in patients with hypertension complicated with stroke. Methods 70 hypertensive patients with stroke were selected as A group, 72 patients with simple hypertension were selected as B group, and 71 healthy subjects were selected as C group.The light transmitting method was used to detect serum Lp-PLA2, and immunoturbidimetry was used to detect plasma D-dimer.The clinical value of the two joint detection and single detection in prediction of hypertension complicated with stroke was analyzed. Results The plasma Lp-PLA2 and D-dimer levels of A group were (471.88±181.49)ng/mL, (982.54±373.28)μg/mL, which were higher than those of B group[(195.17±34.74)ng/mL, (263.57±29.70)μg/mL] and C group[(122.94±46.25)ng/mL, (96.44±8.49)μg/mL](F=189.7, 171.1, all P=0.000). The plasma Lp-PLA2 level of A group was positively correlated with D-dimer(r=0.692, P 252g/mL forecast hypertension stroke risk sensitivity was 83.3% and specificity was 98.6%, the plasma Lp-PLA2>176.36ng/mL forecast hypertension stroke risk sensitivity was 92.9% and specificity was 83.1%, and the combined prediction of hypertension stroke risk sensitivity was 87.6%, specificity was 93.5%. Conclusion The plasma levels of Lp-PLA2 and D-dimer are significantly increased in hypertensive patients with stroke, and the combined detection of the two indicators can improve the prediction of stroke risk in patients with hypertension. Key words: Hypertension; Apoplexy; Plasma lipoprotein phospholipase A2; D-dimer