The Clinical study of atorvastatin therapy of different doses on hs-CRP leves in patients in early phase with acute myocardial infarction

Abstract

Objective To investigate the effect of different doses of atorvastatinon on serum high sensitivity C-reactive protein and blood lipid levels in early phase of acute myocardial infarction. Methods A total of 60 patients with AMI were randomly assigned into the large dosage of atorvastatin(40 mg/d)group(n=30) and the routine dosage of atorvastatin(20 mg/d) (n = 30). Serum levels of blood lipid, hs-CRP were measured with biochemistry assay 24 hour after admission and 3 days and 7 days after therapy. The difference in blood lipid, hs-CRP was compared between the two groups. Results Among the two groups, the levels of TC and LDL-C decreased significandy after treatment(P ＜ 0. 05), in the large dosage of atorvastatin group, the levels of hs-CRP decreased significandy comparing with the routine dosage of atorvastatin group(P ＜ 0. 01) , but no visible statistic differences were found in TC, and LDL-C among the two groups. Conclusion Effect of early atorvastatin therapy of the large dosage on serum hs-CRP leves is better than the routine dosage in patients with acute myocardial infarction. The anti-inflammatory effect of atorvastatin is not related to lipid lowering. Key words: Atorvastatin; Blood lipid; High sensitivity C-reactive protein; Acute myocardial infarction