Abstract
Objective To explore the correlation between hepatitis B virus large surface protein(HBV-LP)and hepatitis B virus deoxyribonucleic acid(HBV-DNA),analyze the clinical significance of detecting the two index dynamically for diagnosis and treatment of hepatitis B.Methods Enzyme linked immunosorbent assay(ELISA)and fluorescent quantitation polymerase chain reaction(FQ-PCR)were used to detect the levels of HBV-LP and HBV-DNA in serum specimen of 230 hepatitis B patients.Results There was a positive correlation between the content of HBV-LP and copy numbers of HBV-DNA in serum of hepatitis B positive cases(r=0.84,P<0.01).The positive rate was 84.78% in HBV-LP and 84.35% in HBV-DNA of 230 HBV positive cases.As a result there was no significant difference(P>0.05)in this study.Therefore,the positive rate was 63.63 %(35/55)in HBV-LP and 58.18%(32/55)in HBV-DNA of 55 HBV negative cases.There was also no significant difference(P>0.05)in this study.However,the positive rate of HBV-LP(82.47%)was higher than HBE(52.06%)in the 194 HBV-DNA positive cases.There was significantly different(P<0.01).Conclusion HBV-LP and HBV-DNA are the significant index of the degree of hepatitis B virus replication in hepatitis B positive cases,especially in determining the virus replication and prognosis of treatment in HBe Ag negative,providing the reliable laboratory data for the clinical diagnosis and treatment. Key words: Hepatitis B large surface protein; Hepatitis B virus; Virus replication
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