The clinical relevance of maternal serum HCY, folic acid and vitamin B12 levels with pregnancy induced hypertension

Abstract

Objective To evaluate the clinical relevance of maternal serum HCY, folic acid (FA) and vitamin B12 (VB12) levels with pregnancy induced hypertension (PIH). Methods 100 pregnant women with PIH were selected as the observation group.100 non-PIH pregnant women at the same period in our hospital were selected as control group.Serum HCY, FA and VB12 levels at trimester, second trimester and third trimester of pregnancy were detected and compared. Results HCY levels at trimester, second trimester and third trimester of pregnancy were (15.07±4.86)μmol/L, (17.82±3.16)μmol/L and (19.25±3.24)μmol/L in the observation group, those were (6.36±2.47)μmol/L, (5.89±2.14)μmol/L and (6.68±2.08)μmol/L in the control group, prenatal HCY levels of the observation group in the three stages were significantly higher (t=15.97, 31.26, 15.97, all P 0.05). FA levels in the observation group at second trimester and third trimester were significantly lower than the control group (t=8.95, 11.06, all P<0.05). VB12 levels at three stages of prenatal in the observation group were significantly lower than the control group (t=4.23, 2.53, 4.23, all P<0.05). Conclusion Serum FA and VB12 levels are deficiency at second trimester and third trimester in PIH pregnant women, and with HCY rising, which may associated with the occurance and development of PIH. Key words: Pregnancy induced hypertension; Cysteine; Folic acid; Vitamin B12