Clinical significance of serum folic acid and vitamin B12 in patients with H-type hypertension

Abstract

Objective To investigate the clinical significance of serum folic acid and vitamin B12 detection in patients with H-type hypertension. Methods A total of 120 patients with primary hypertension admitted to Shanxi Cardiovascular Hospital from October 2015 to October 2016 were selected. Among them, 64 cases of H-type hypertension were assigned to group A , and 56 cases of simple hypertension to group B. In addition, 60 healthy patients who went to hospital for physical examination during the same period were selected as the control group. Five ml fasting venous blood was taken from patient’s elbows in the morning. Aerum folic acid, vitamin B12 and homocysteine (Hcy) levels were measured after centrifugation. Serum folic acid, vitamin B12 and Hcy levels were observed and recorded. The correlation between serum folic acid, vitamin B12 and Hcy levels and H-type hypertension was analyzed. Results Serum levels of folic acid and vitamin B12 in group A were lower than those in group B and control group, and Hcy levels were higher than those in group B and control group, with statistically significant differences (P 0.05). Pearson correlation analysis showed that serum folate and vitamin B12 levels were negatively correlated with H-type hypertension (r 0, P<0.05), that was, with the decrease of serum folic acid and vitamin B12 levels, the serum Hcy level increased, and the patients had a higher risk of developing H-type hypertension. Conclusions The detection of serum folic acid, vitamin B12 and Hcy has important value in the diagnosis of early H-type hypertension, and provides important basis for the formulation of individualized clinical treatment plan. Key words: H-type hypertension; Serum folate; Vitamin B12