The clinical pathology characteristic of 42 example early time stomach cancer

Abstract

Objective To observe early gastric endoscopy, clinical and pathological features of the pathological diagnosis. Methods 42 cases of early gastric cancer of clinical, endoscopic and pathological features was observed, C-erbB2, P53, Ki-67 expression were detected by immunohistochemical sp method. Results The results of early gastric cancer had no specific, mainly abdominal pain and bloating discomfort, some weight loss loss of appetite, vomiting blood in the stool, etc. , endoscopy showed erosive flat major, 23 cases (54. 8% )protruded in 17 cases (40. 5% ), lesions up to 29 cases of gastric area, gastric angle in 5 cases, 6 cases of gastric body and gastric cardia in 2 patients. Organization type: tubular adenocarcinoma, 24 cases,2 cases of mucinous adenocarcinoma, signet ring cell carcinoma in 7 cases, 9 cases of poorly differentiated adenocarcinoma, 15 cases associated with intestinal metaplasia, dysplasia in 14 cases. Mucosal carcinoma in 26 patients, submucosa in 16 cases, 6 cases with lymph node metastasis. C-erbB-2 expression accounted for 16. 7%(7/42) , Ki-67 expression accounted for 38. 1% (16/42), P53 expression accounted for 30. 9% (13/42).Conclusion The clinical manifestations of early gastric cancer is hidden, non-specific, not enough to cause attention to patients and clinicians. High risk of gastric cancer patients with gastroscopy active on a regular basis to improve the detection rate of early gastric cancer is the key to the early diagnosis of gastric cancer. C-erbB-2 expression is related to lymph node metastasis. Factors of early gastric cancer is a multi-step interaction of multiple genes and more complex process. Key words: Clinical pathology; Early the stomach cancer; Gastrosscope; Immunohistochemical