The clinical effect of Cold-Knife Conization in patients with early cervical cancer and its influence in the pregnancy outcome

Abstract

Objective To study the clinical effect of Cold-Knife Conization (CKC) in patients with early cervical cancer and its influence in the pregnancy outcome. Methods 40 early cervical cancer patients of adopting the CKC from January 2010 to September 2012 in our Department were selected as observation group.40 early cervical cancer patients without history of cervical conization were selected as control group. All patients were followed up for 8 to 36 months. Tumor recurrence, pregnancy and maternity history and pregnancy outcomes were recorded and compared between groups. Results In the observation group, 32 cases were pregnant (the success rate of pregnancy was 80.0%), of which 4 cases were aborted and the delivery rate was 87.5%. In the control group, 39 cases were pregnant(the success rate of pregnancy was 97.5%) , no abortion was found, and the delivery rate was 100.0%. The pregnancy rate and delivery rate in the observation group were lower than those in the control group (P 0.05). The observation group had 8 cases (28.6%) premature delivery, 9 cases (32.1%) neonatal asphyxia, 6 cases (21.4%) premature rupture of membranes, and the average weight of neonates was (2 842.17±48.99)g. The control group had 3 cases (7.7%) premature delivery, 1 case (2.6%) neonatal asphyxia, 2 cases (5.1%) premature rupture of membranes, and the average weight of neonates was (3 243.81±51.02)g. The perinatal premature birth rate, neonatal asphyxia rate and premature rupture rate of membranes in the observation group were higher than those in the control group, and the average weight of newborns was lower than that in the control group, with statistically significant difference (P<0.05). During the follow-up period, the recurrence rate of the observation group was lower than that of the control group [2.5% (1/40) vs 17.5% (7/40)], with statistical significant significance (P<0.05). Conclusions Although cold knife conization can reduce the recurrence rate of early cervical cancer patients, the fertility and pregnancy outcomes of patients after operation is greatly affected. Careful selection should be made in clinical treatment according to the actual situation. Key words: Uterine cervical neoplasms/SU; Electrosurgery; Neoplasm recurrence, local; Pregnancy outcome