The clinical application observation of three drugs to promote cervical ripening

Abstract

Objective To observe the efficacy and safety of three drugs(dinoprostone suppositories,misopmstol and oxytocin) to promote cervieal ripening.Methods A randomized control study method was used.The 180 primipara was divided into 3 groups.Group A:dinoprostone suppositories,Group B:low-dose misoprostol,Group C:oxytocin.The maternal cervical Bishop score of three drugs being used before and after 4,8,12 h was compared between the three groups,as well as the labor situation,the rate of fetal distress and neonatal asphyxia after the drugs.Results The effective rates of groups A,B,C were 88.3%,85.0%,35.0%.The cesarean section rates of three groups were 21.7%,25.0%,60.0%.There was significantly different between groups A,B with group C(P＜0.05).Conclusion Dinoprostone suppositories and misoprostol were safe and effective,and they had a high success rate of clinical application.Then Oxytocin was ill effect. Key words: Dinoprostone suppositories; Misoprostol; Oxytocin; Bishop score