The clinical analysis of 19 cases of stroke complicating polycythemis vera

Abstract

Objective To explore the clinical features and treatment of stroke complicating polycythemia vera(PV). Methods Clinical data of 19 cases of stroke complicating PV were analysed retrospectively.Results ①Among all the cases, cerebral infarction complicating PV were 14 cases (14/19,73.4%), among the 14 cases, 12 cases(12/14,85.7%) of multiple cerebral infarction, 2 cases(2/15,13.3%) of transientischemis attack ;2 cases (2/19,10. 5 %) of cerebral hemorrhage, 1 case (1/19,5.3 %) of subarachnoid hemorrhage (SAH). The patients's clinical manifestation, physical sign, hemogram, marrow characteristic were consistentwith that of PV diagnosis criteria. ② Imageology check show that small infarction focus were common (13/19,68.4%). Lobe of brain, basal ganglia, capsula intema were common place of cerebral infarction. The density of hemorrhagic focus was asymmetrical, there was obvious edema around the hem orrhagic focus. ③Applied vein blood-letting and small dose chemotherapy, 7 cases were covery, 11 cases were obviously inproved, 1 case of stroke was invalid. Conclusion The cerebral infarction is common in stroke complicating PV. Among all the stroke complicating PV cases, multiple cerebral infarction are the most common, cerebral hemorrhage and subarachnoid hemorrhage are few, vein blood-letting and small dose chemotherapy has a good curative effect for the patients. Key words: Polycythemia vera; Stroke; Treatment