Abstract
目的 探讨血清Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)与糖尿病肾病(DN)的相关性及血管紧张素转换酶抑制剂(ACEI)干预治疗对其影响.方法选择2型糖尿病(DM)患者166例及正常对照(NC)55例,根据尿白蛋白排泄率(UAER),将2型DM患者分为正常蛋白尿组(NA)、微量蛋白尿组(MA)、临床蛋白尿组(ODN),分别检测各组的血清Ⅳ-C、LN,并观察干预治疗后上述指标的变化.结果2型DM患者血清Ⅳ-C、LN水平高于NC组(P＜0.01),DM患者从NA组、MA组到ODN组,血清Ⅳ-C、LN逐渐增高,各组间差异有显著意义(P＜0.01).MA组和ODN组经干预治疗后,血清Ⅳ-C、LN水平较前有显著性降低,UAER较前有显著性下降.结论血清Ⅳ-C、LN水平变化与DN的发生发展密切相关,早期应用ACEI有助于防止或延缓DN的病理学进展。
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