The change of BNP and hs-CRP levels in coronary heart disease patients with heart failure

Abstract

Objective To investigate the relationship between coronary heart disease patients with heart failure and natriuretic peptide （BNP） and c-reactive protein（ hs-CRP）, and provide the clinical basis. Methods 160 coronary heart disease patients with heart failure were selected as the observation group, and 200 health individuals as the control group. The BNP and hs-CRP with heart failure were analyzed. Results BNP and hs-CRP of the observation group were （481.5 ± 57.8 ）pg/mL and （12.4 ± 2.9）mg/L, which were higher than that of the control group [ （41.2 ± 9.6 ） pg/L vs （3.8 ± 1.1 ） mg/L ], the difference was statistically significant （ t = 13.17,5.28, all P 〈 0.05 ） ; Left ventricular ejection fraction（LVEF） of the observation group was （all. 9 ± 6.3 ） %, lower than that of the control group （60.2 ± 8.4） %, the difference was statistically significant（ P 〈 0.05 ） ; BNP and hs-CRP of grade Ⅰ , Ⅱ, Ⅲ and Ⅳ increased with the grade, the differences were statistically significant （ t = 5.20,10. 11,12.42,4. 18,5.02,3.98, all P 〈 0. 05 ） ; By Logistic analysis, serum BNP and hs-CRP were associated with heart failure of coronary heart disease. Conclusion Coronary heart disease patients with heart failure cardiac function were associated with BNP and hs- CRP, and with grade were gradually increasing that BNP and hs-CRP increased. Key words: Hrain natriuretic peptide ; C-reactive protein ; Heart failure ; Coronary heart disease