Abstract
The mammalian Rh glycoproteins belong to the solute transporter family SLC42 and include the erythroid Rhâassociated glycoprotein (RhAG) and two epithelial membrane molecules Rhbg (human RhBG) and Rhcg (RhCG). Mammalian Rh glycoproteins are closely related to the ammonium transporters of the yeast (MEP proteins) and bacteria (Amt). Rhbg and Rhcg are expressed in several mammalian tissues including liver, kidney, skin, lung, and GI tract. In the kidney they are expressed in αâintercalated cells and principal cells of the collecting duct. Whereas Rhbg is strictly present in the basolateral membrane; Rhcg is reported to be at both apical membrane and basolateral membranes. Recent functional studies strongly support a role of Rh glycoproteins in NH4+ transport. Other studies indicate that they mediate transport of CO2 and NH3. This review highlights the progress in determining the properties of Rh glycoproteins and the challenging questions that continue to hinder understanding their function and their physiological role. WIREs Membr Transp Signal 2014,3:53â61. doi: 10.1002/wmts.105For further resources related to this article, please visit the WIREs website.Conflict of interest: The authors have declared no conflicts of interest for this article.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
