Abstract
Since the work of Thudichum, evidence has existed that there was more than one cerebroside. On the basis of physical properties and analyses, Thudichum distinguished two cerebrosides, phrenosin and kerasin. He had the correct intuition as to the points of difference of the two cerebrosides, and suggested that this difference was in the nature of one component, namely, the fatty acid. As far as he worked, the other components were identical in all cerebrosides. Unfortunately his method of separation was imperfect. Therefore, each fraction contained a large portion of the other. When the fatty acids were obtained, they analyzed approximately for a stearic acid, which Thudichum named neuro stearic acid. Subsequent workers improved the methods of purification particularly that of phrenosin; this permitted the isolation of the fatty acid, cerebronic acid. This acid was identified by Thierfelder as an hydroxy pentacosanic acid, C25H50O3. The further work on cerebrosides brought nothing new as regards their stru...
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