Abstract
Summary When 40-mg doses of 1–3 μ quartz particles in a 4-ml normal saline were injected intracardially in each of fifteen guinea pigs, normal blood clotting was prevented for several hours. Eleven animals died from “silica shock.” Colloidal aluminum hydroxide, particulate oxidized metallic aluminum, and precipitated aluminum hydrate similarly administered have no significant effect on blood globulins. On injection of the aluminum agents in various doses simultaneously with the quartz, prothrombin depression is inhibited by the colloidal aluminum hydroxide and by aluminum hydrate, but not by particulate metallic aluminum. Dissolved silica Si(OH) 4 has no effect on blood clotting, and the supernatant fluid from a suspended mixture of quartz and aluminum hydrate proved to be equally inert. All the guinea pigs which had received the quartz plus aluminum hydrate or quartz plus metallic particulate aluminum died; thus colloidal aluminum hydroxide remains as the only safe intravascularly administered antidote against silica. The prothrombin depression is due to the protein-denaturing action of forces at the surface of quartz particles. These forces are nullified by adsorbed colloidal aluminum hydroxide.
Published Version
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