Abstract
To investigate the distribution of Rh phenotype, irregular antibodies screenting and postpartum follow-up of RhD- pregnant women in Xiamen. The samples of 313 RhD- pregnant women from June 2018 to May 2020 were collected. Rh serotype phenotypes were identified by tube physiological saline method, irregular antibodies were screened and confirmed by DiaMed Low ion indirect anti-human gel card. By recording the medical，the pregnant women production process and the occurrence of HDN were investigated. The Rh serological phenotypes of 313 RhD- pregnant women were ccdee 180 cases (57.51%), Ccdee 97 cases (30.99%), ccdEe 10 cases(3.19%), CCdee 21 cases (6.71%), CcdEe 5 cases (1.60%), the ccdee and ccdee were the most common in the serological phenotype. Eleven irregular antibodies were detected in 313 RhD- pregnant women, accounting for 351% of the total. There were 8 cases of anti-D antibody, 1 case of anti-E antibody, and 2 cases of anti-D combined with anti-C antibody. The medical records of 21 RhD- pregnant women were reviewed, 19 cases of RhD+ and 2 RhD- newborns were successfully delivered, in which 2 cases developed RhD-HDN, 1 case developed RHE-HDN, and the remaining 18 cases did not develop HDN. The Rh serological phenotype of RhD- pregnant women in Xiamen area is mainly for ccdee. Maternal history and blood transfusion history are the main causes of irregular RhD- pregnant antibodies. It is recommended that serological phenotype combined with irregular antibody screening should be applied for RhD- pregnant women in clinic, to reduce the risk of RhD-HDN and ensure the safety of RhD- blood transfusion.
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