Abstract
The sensitivity of Escherichia coli 15 TAU to killing by ultraviolet light (2537 Å) when grown for various times under several nutritionally restricted conditions (+T−AU; −T+AU; −T−AU) has been measured. Concurrent measurements were made on the amount of DNA crosslinked to protein by these same doses of ultraviolet light. There appears to be a direct correlation between the amount of DNA crosslinked to protein by a given dose of ultraviolet light and the intrinsic sensitivity of the cells to killing by ultraviolet light under the several growth conditions studied. These results strongly suggest that the crosslinking of DNA and protein by physiological doses of ultraviolet light must play an important role in the loss of viability of ultraviolet light irradiated cells.
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