Abstract
The biodistribution of [ 75Se]BISTAES was studied in guinea pigs. A higher concentration of radioactivity was observed in articular cartilage than in other tissues or organs. A minimal amount of radioactivity was found in the blood, muscle and bone. The compound was excreted rapidly in urine. The target to background ratios were encouraging. [ 75Se]BISTAES has potential as an articular cartilage imaging agent and further studies in osteoarthritic animals are merited.
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