Abstract
The Availability of Surface GABAB Receptors Is Independent of γ-Aminobutyric Acid but Controlled by Glutamate in Central Neurons
Highlights
SEPTEMBER 5, 2008 VOLUME 283 NUMBER 36 azole propionate receptors modifies synaptic strength and influences experience-dependent plasticity in vivo [4]
GABAB receptors (GABABRs) were transfected into hippocampal neurons, and the fate of surface receptors was subsequently followed by immunoendocytosis
Abundant GABABR1 concentrated at the plasma membrane after transfection, and a significant proportion accumulated in intracellular compartments after 60 min of endocytosis (Fig. 1, A and B, arrows)
Summary
SEPTEMBER 5, 2008 VOLUME 283 NUMBER 36 azole propionate receptors modifies synaptic strength and influences experience-dependent plasticity in vivo [4]. Endocytosis of GABAB Receptors in Neurons report that internalization of GABABRs is agonist-independent and that the mechanism depends on clathrin and dynamin-1. Abundant GABABR1 concentrated at the plasma membrane after transfection, and a significant proportion accumulated in intracellular compartments after 60 min of endocytosis (Fig. 1, A and B, arrows).
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