Abstract
Abstract Objective: The present study aimed to evaluate the association of serum sialic acid (SA) levels with nitric oxide (NO) and C-reactive protein (CRP) in patients with diabetic foot ulcer. Methods: This study included total 56 type 2 diabetic patients (27 of them had diabetic foot ulcer and 29 without it) and 22 healthy volunteers. Serum SA, NO and CRP levels were measured with spectrophotometric and nephelometric methods respectively. Results: Serum SA levels were higher in diabetic foot group than diabetes group (p<0.05). CRP and NO levels were found to be significantly higher in diabetic foot group compared to the diabetes (p<0.001 and p=0.002, respectively) and control groups (p<0.001, both). Although there was no correlation between SA and NO (p>0.05), serum SA levels were significantly correlated with CRP in diabetic foot group (p<0.001). Conclusion: We suggest that SA could be related to acute phase response in patients with diabetic foot ulcer. Elevated serum SA and NO levels may be indicators of oxidative stress-induced vascular damage.
Published Version
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