Abstract
Background: The primary objective of this study was to explore the association of hypertriglyceridemic waist (HTGW) phenotype with chronic kidney disease (CKD) and its sex difference in an urban Chinese elderly population. Methods: In a cross-sectional study, a total of 2102 participants aged 60–95 years were recruited and classified into four phenotypes: normal waist-normal triglyceride (NWNT), normal waist-elevated triglycerides (NWET), elevated waist-normal triglycerides (EWNT), and HTGW. Logistic regression analysis was used to estimate the associations of interest. Results: Total prevalence of CKD was 12.6%, and the CKD prevalence in participants with EWNT and HTGW was higher than with NWNT and NWET without regard to sex. Compared to NWNT phenotype, the adjusted OR for CKD was 1.95 (95% CI: 1.32–2.88) in HTGW groups. In contrast with the null findings (OR: 1.66; 95% CI: 0.94–2.94) in women after additional adjustment for diabetes and hypertension, the OR with HTGW remained strong (OR: 1.88; 95% CI: 1.04–3.39) in men. Similar findings appeared with the EWNT phenotype. Conclusions: The HTGW phenotype is positively associated with CKD among Chinese community elderly and may have a greater impact on men. More attention should be paid to the association between triglycerides and waist circumference in clinical practice and to the further identification this uncertain sex-related association.
Highlights
Chronic kidney disease (CKD) was prevalent worldwide in the middle-aged and aged population, and has been recognized as an important disease threatening human health [1]
Previous studies about the hypertriglyceridemic waist (HTGW) phenotype rarely concerned about other simultaneous triglyceride waist phenotypes, which were always combined as a subgroup to analyze. In this cross-sectional study, we explored the sex-specific association of HTGW and three other triglyceride waist phenotypes with chronic kidney disease (CKD) based on an elderly population in Beijing, China
The association reduced to null after adjustment for diabetes and hypertension, but with a large range of confidence interval (OR: 1.67; 95% confidence intervals (CIs): 0.94–2.94)
Summary
Chronic kidney disease (CKD) was prevalent worldwide in the middle-aged and aged population, and has been recognized as an important disease threatening human health [1]. A recent meta-analysis of global observational studies estimating CKD prevalence reported that the pooled CKD prevalence of five stages was 13.4% (11.7%–15.1%) in general populations [2]. The primary objective of this study was to explore the association of hypertriglyceridemic waist (HTGW) phenotype with chronic kidney disease (CKD) and its sex difference in an urban Chinese elderly population. Methods: In a cross-sectional study, a total of 2102 participants aged 60–95 years were recruited and classified into four phenotypes: normal waist-normal triglyceride (NWNT), normal waist-elevated triglycerides (NWET), elevated waist-normal triglycerides (EWNT), and HTGW. Results: Total prevalence of CKD was 12.6%, and the CKD prevalence in participants with EWNT and HTGW was higher than with NWNT and NWET without regard to sex. Conclusions: The HTGW phenotype is positively associated with CKD among Chinese community elderly and may have a greater impact on men. More attention should be paid to the association between triglycerides and waist circumference in clinical practice and to the further identification this uncertain sex-related association
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
