The Association between Hyperuricemia in First Trimester and the Development of Gestational Diabetes

Abstract

Objective: This study aimed to assess the accuracy of the elevation of serum uric acid in the first trimester as a predictive test for development of gestational diabetes mellitus. Patients and methods: It was a prospective observational study included 200 pregnant patients who were regularly attending the out-patient clinic for routine antenatal care to find if the elevated first trimester uric acid is associated with development of GDM or not. Results: The risk of developing GDM was higher if first-trimester uric acid was <3.1 mg/dL. Women who developed GDM were significantly older when they compared to women who did not develop GDM (Normal with Mean+SD 24.53+4.40 years, Abnormal with Mean+SD 32.78+8.18 years, p-value 0.016). It was found that, the mean BMI was significantly higher in women who developed GDM when compared to women who did not develop GDM (Normal 115 cases of total sample and no one developed GD with Mean+SD, 95.57+12.32, Overweight 59 cases, 56 cases (29.3%) were normal and 3 cases (33.3%) had GD with Mean+SD 106.29+26.62, Obese 26 cases, 20 cases (10.5%) were normal and 6 cases (66.7%) had GD with Mean+SD 124.27+39.78, p-value 0.000). Conclusion: Elevated first-trimester uric acid concentration was correlated with an increased risk of developing GDM.