Elevated Serum Uric Acid And Heart Failure In U.S. Adults: 2007-2016 NHANES

Abstract

There is limited evidence examining the relationship between elevated serum uric acid (UA) concentration and heart failure (HF) in U.S. adults. PURPOSE: Examine the associations between elevated UA and HF using a nationally representative sample of U.S. adults. METHODS: The final sample with complete data for this analysis (N=17,412) included men and women aged ≥40 years who participated in the 2007-2016 National Health and Nutrition Examination Survey. Self-reported diagnosis of HF was assessed via interview. Elevated UA was defined as values >6.0 mg/dL for women and >7.2 mg/dL for men. Multivariable gender-stratified logistic regression was utilized to examine the odds of HF. RESULTS: The estimated prevalence of HF was 3.85% and 3.39% among men and women, respectively. Age adjusted analysis revealed significantly increased odds of HF in men (odds ratio [OR], 2.78; 95% confidence interval [CI] 2.09-3.71, P<0.01) and women (OR, 3.25; 95% CI 2.37-4.45, P<0.01) with elevated UA. Significance remained following adjustment for education, income, race, body mass index, alcohol consumption, hypertension, diabetes, physical activity, and creatinine in men (OR, 1.59; 95% CI 1.04-2.43 P=0.03) and women (OR, 2.03; 95% CI 1.33-3.08, P<0.01). CONCLUSIONS: In a representative sample of U.S. adults, having an elevated UA concentration was associated with significantly increased odds of HF when compared to adults with normal UA.