The application value of aEEG and NBNA in the early evaluation on brain damage for full-term neonates with hyperbilirubinemia

Abstract

Objective To investigate the application value of amplitude integrated electroencephalogram (aEEG) and neonatal behavioral neurological assessment(NBNA) in the early evaluation on brain damage for full-term neonates with hyperbilirubinemia. Methods From August 2015 to February 2016, 42 full-term neonates with hyperbilirubinemia were divided into two groups:subclinical bilirubin encephalopathy group and hyperbilirubinemia control group according to the results of magnetic resonance imaging(MRI), while 20 normal healthy full-term infants born in our hospital at the same time were chosen as normal control group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Clinic Medical College of Yangzhou University. Informed consent was obtained from each parents.The serum level of total bilirubin(TB), the score of NBNA, the abnormality rate for brainstem auditory evoked potential (BAEP) and aEEG were compared among three groups,meanwhile the correlation for these parameters were assayed. Results (1)There were significant differences in the level of UCB ,the score of NBNA, the abnormality rate of BAEP and aEEG among different groups (F=20.16, 7.12,χ2=15.18,12.23,P 0.05). (2)Of the 7 mildly abnormal aEEG cases in the subclinical bilirubin encephalopathy group, 6 mildly abnormal and 1 moderately abnormal were found in BAEP test. All of the 9 severely abnormal aEEG cases in the subclinical bilirubin encephalopathy group were found 1 moderately abnormal and 8 severely/very severely abnormal of BAEP. By linear correlation analysis,the abnormality degree of aEEG was positively correlation with BAEP (γ=0.806,P=0.032). (3)22 cases of subclinical bilirubin encephalopathy group inclued 16 abnormal aEEG cases (72.73%) and 21abnormal aEEG with NBNA cases (95.45%) respectively,there were statistically significant differences (χ2=4.08,P<0.05). Conclusion aEEG combining with NBNA may be an reference indicator for early evaluation on brain damage in full-term neonates with hyperbilirubinemia. It has great clinical important value and can be worth popularizing. Key words: aEEG; NBNA; Neonate; Hyperbilirubinemia; Brain damage