Abstract
Objective To investigate the application and the effect of TNF-α,IL-6 in plasm of continuous blood purification in patients with multiple organ disorder syndrome （MODS）. Methods Twenty-six patients with MODS were treated by CBP. Blood markers of biochemistry, blood routine and TNF-α, IL-6 in plasm were checked before and after treatment. Results Blood levels of Scr,BUN, WBC,CRP, TNF-α, IL-6 after treatment were significandy lower than those before treatment of CBP （ P 〈 0.05, P 〈 0.01 ）, and blood levels of pH and HCO2^- after treatment were significantly higher than those before treatment of CBP（P 〈 0.05, P 〈 0.01 ）. 8 patients survived in the 26 patients and the survival rate was 31% . Conclusion In the patients with MODS,CBP can efficiendy treat the water-electrolyte disturbance,keep the acid-base balance,clear the inflammatory mediator and protect organs injured further,improve the patients＇ condkion and increase the survival rate. Key words: Continuous blood purification; Multiple organ disorder syndrome; Cytokines
Published Version
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